Spironolactone is used to treat many different disorders, from high blood pressure to fluid retention. Although the U.S. Food and Drug Administration doesn't recognize "spironolactone as an acne treatment", it is often prescribed off-label to treat hormonally influenced breakout in women.
This medication isn't a first line of defense against acne breakouts. It is only effective against acne caused by hormonal fluctuations. But it can be especially helpful for women with hormonal disorders that trigger acne or who suffer with other problems, like unwanted facial hair.
Spironolactone is only available by prescription from your doctor. It is also sold under the brand name Aldactone .